Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

Cancer Res. 1994 Sep 15;54(18):4855-78.

Authors

M S Greenblatt¹, W P Bennett, M Hollstein, C C Harris

Affiliation

¹ Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892.

PMID: 8069852

No abstract available

Publication types

Review

MeSH terms

Aflatoxins / toxicity
Animals
Cell Transformation, Neoplastic / genetics
Chromosome Deletion
Conserved Sequence
DNA Damage
DNA Mutational Analysis
DNA Repair
DNA Replication
Disease Models, Animal
Genes, p53 / genetics*
Genes, p53 / physiology
Hepatitis B / complications
Humans
Mutation / genetics*
Neoplasms / etiology
Neoplasms / genetics*
Neoplasms, Radiation-Induced / genetics
Phenotype
Sequence Analysis, DNA
Smoking / adverse effects
Structure-Activity Relationship
Tumor Suppressor Protein p53 / chemistry
Tumor Suppressor Protein p53 / physiology

Substances

Aflatoxins
Tumor Suppressor Protein p53