Abstract
Infection with the murine coronavirus strain JHM decreases cell surface expression of major histocompatibility complex class I antigens. Northern blots showed that JHM virus infection rapidly reduced the level of actin mRNA, whereas the levels of major histocompatibility complex class I and tubulin mRNAs were reduced only slightly. By contrast, the mRNA levels of interleukin 1 beta, colony-stimulating factor 1 receptor, and tumor necrosis factor alpha increased following infection.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Actins / biosynthesis
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Animals
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Antibodies, Monoclonal
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Antibody Specificity
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Cell Line
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Cell Membrane / immunology
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Cell Membrane / metabolism
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Coronavirus / pathogenicity*
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Coronavirus / physiology*
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Histocompatibility Antigens Class I / biosynthesis*
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Interleukin-1 / biosynthesis
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Kinetics
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L Cells
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Mice
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RNA, Messenger / biosynthesis*
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RNA, Messenger / isolation & purification
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RNA, Viral / biosynthesis*
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RNA, Viral / isolation & purification
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Receptor, Macrophage Colony-Stimulating Factor / biosynthesis
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Time Factors
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Actins
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Antibodies, Monoclonal
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Histocompatibility Antigens Class I
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Interleukin-1
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RNA, Messenger
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RNA, Viral
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Tumor Necrosis Factor-alpha
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Receptor, Macrophage Colony-Stimulating Factor