The gene coding for the alpha 1 subunit of the skeletal dihydropyridine receptor (Cchl1a3 = mdg) maps to mouse chromosome 1 and human 1q32

Mamm Genome. 1993 Sep;4(9):499-503. doi: 10.1007/BF00364784.

Abstract

Using both chromosomal in situ hybridization and molecular techniques, we report the genetic localization of the gene coding for the alpha 1 subunit of the skeletal slow Ca2+ current channel/DHP receptor gene (Cchl1a3) on human Chromosome (Chr) 1 (1q31-1q32 region) and on mouse Chr 1 (region (F-G)). On the basis of single-strand conformation polymorphism (SSCP-PCR) analysis in an interspecific backcross, we have determined that the Cchl1a3 = mdg (muscular dysgenesis) locus is very closely linked to the myogenin (Myog) locus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Bone and Bones / metabolism*
  • Calcium Channels / genetics*
  • Calcium Channels / metabolism
  • Calcium Channels, L-Type
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • Crosses, Genetic
  • DNA Primers
  • Humans
  • In Situ Hybridization
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Muridae
  • Muscle Proteins / genetics*
  • Polymorphism, Genetic
  • Receptors, Cholinergic / genetics*
  • Receptors, Cholinergic / metabolism

Substances

  • Calcium Channels
  • Calcium Channels, L-Type
  • DNA Primers
  • Muscle Proteins
  • Receptors, Cholinergic