Management of acute diarrhoea in diabetic patients using oral rehydration solutions containing glucose, rice, or glycine

BMJ. 1994 Mar 5;308(6929):624-6. doi: 10.1136/bmj.308.6929.624.

Abstract

Objective: To assess the risk of hyperglycaemia with two standard oral rehydration solutions that contain carbohydrate compared with a carbohydrate free solution during rehydration of diabetic patients with acute diarrhoea.

Design: Prospective randomised allocation to one of three oral rehydration solutions (World Health Organisation (glucose), rice, or glycine) groups after admission to hospital with acute diarrhoea.

Setting: Dhaka hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh.

Subjects: 45 diabetic patients aged between 15 and 60 who had had diarrhoea for fewer than three days on admission.

Main outcome measures: Fluctuation of blood glucose concentrations measured three times a day, daily stool output, and time taken for recovery from diarrhoea.

Results: There were no significant differences in blood glucose concentrations, stool output, and duration of recovery from diarrhoea among the three groups.

Conclusions: Oral rehydration solutions containing glucose, rice powder, or glycine can be safely administered to diabetic patients with acute diarrhoea and some dehydration.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Blood Glucose / analysis
  • Defecation
  • Diabetes Complications*
  • Diarrhea / blood
  • Diarrhea / complications
  • Diarrhea / therapy*
  • Female
  • Fluid Therapy*
  • Glucose / administration & dosage*
  • Glycine / administration & dosage*
  • Humans
  • Length of Stay
  • Male
  • Middle Aged
  • Oryza*
  • Prospective Studies

Substances

  • Blood Glucose
  • Glucose
  • Glycine