Short-sighted evolution and the virulence of pathogenic microorganisms

Trends Microbiol. 1994 Mar;2(3):76-81. doi: 10.1016/0966-842x(94)90538-x.

Abstract

For some microorganisms, virulence may be an inadvertent consequence of mutation and selection in the parasite population, occurring within a host during the course of an infection. This type of virulence is short-sighted, in that it engenders no advantage to the pathogen beyond the afflicted host. Bacterial meningitis, poliomyelitis and AIDS are three candidates for this model of the evolution of virulence.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / microbiology
  • Bacteria / pathogenicity
  • Biological Evolution*
  • HIV / pathogenicity
  • Humans
  • Meningitis, Bacterial / microbiology
  • Mutation
  • Poliomyelitis / microbiology
  • Poliovirus / pathogenicity
  • Virulence*