Complexes of Cu(II) with Asn-Ser-Phe-Arg-Tyr-NH2; an example of metal ion-promoted conformational organization which results in exceptionally high complex stability

J Inorg Biochem. 1993 Nov 1;52(2):79-87. doi: 10.1016/0162-0134(93)85024-3.

Abstract

The pentapeptide fragment of ANF, Asn-Ser-Phe-Arg-Tyr-NH2, coordinates to Cu(II) using the same four nitrogen donor centers as simple pentapeptides such as pentaalanine yet the complexes are of much higher stability as a result of a highly organized side-chain structure which is present in the complex but absent from the free ligand.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Atrial Natriuretic Factor / chemical synthesis
  • Atrial Natriuretic Factor / chemistry*
  • Atrial Natriuretic Factor / metabolism
  • Circular Dichroism
  • Copper*
  • Drug Stability
  • Molecular Sequence Data
  • Oligopeptides / chemistry*
  • Peptide Fragments / chemical synthesis
  • Peptide Fragments / chemistry*
  • Potentiometry
  • Protein Binding
  • Protein Conformation*
  • Structure-Activity Relationship

Substances

  • Oligopeptides
  • Peptide Fragments
  • asparaginyl-seryl-phenylalanyl-arginyl-tyrosinamide
  • Copper
  • Atrial Natriuretic Factor