Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel

Biochem Biophys Res Commun. 1993 Dec 15;197(2):922-6. doi: 10.1006/bbrc.1993.2567.

Abstract

Partial complementary DNAs for the epsilon 1, epsilon 3 and zeta 1 subunits of the human N-methyl-D-aspartate (NMDA) receptor channel were cloned using the corresponding mouse subunit cDNA clones as probes. Genomic DNA clones for the human epsilon 1, epsilon 3 and zeta 1 subunit genes were isolated using the corresponding partial cDNA clones as probes. By the fluorescence in situ hybridization, we mapped the genes for the epsilon 1, epsilon 3 and zeta 1 subunits of the human NMDA receptor channel to chromosomes 16p13, 17q25 and 9q34, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cerebral Cortex / metabolism
  • Chromosome Mapping
  • Chromosomes, Human, Pair 16*
  • Chromosomes, Human, Pair 17*
  • Chromosomes, Human, Pair 9*
  • Cloning, Molecular
  • DNA Probes
  • DNA, Complementary / metabolism
  • Gene Library
  • Humans
  • In Situ Hybridization, Fluorescence
  • Macromolecular Substances
  • Receptors, N-Methyl-D-Aspartate / genetics*

Substances

  • DNA Probes
  • DNA, Complementary
  • Macromolecular Substances
  • Receptors, N-Methyl-D-Aspartate