Dysregulation of striato-nigral GABAergic pathway by chronic haloperidol treatment: the role of dopamine D1 receptor in the substantia nigra pars reticulata on the development of tardive dyskinesia

Jpn J Psychiatry Neurol. 1993 Jun;47(2):429-30. doi: 10.1111/j.1440-1819.1993.tb02136.x.

Authors

O Shirakawa¹, K Maeda, K Sakai

Affiliation

¹ Department of Psychiatry and Neurology, Kobe University School of Medicine.

PMID: 8271625
DOI: 10.1111/j.1440-1819.1993.tb02136.x

No abstract available

MeSH terms

Animals
Corpus Striatum / drug effects*
Corpus Striatum / physiopathology
Dyskinesia, Drug-Induced / physiopathology*
Haloperidol / pharmacology*
Male
Mastication / drug effects
Mastication / physiology
Neural Pathways / drug effects
Neural Pathways / physiopathology
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1 / drug effects*
Receptors, Dopamine D1 / physiology
Receptors, Dopamine D2 / drug effects
Receptors, Dopamine D2 / physiology
Receptors, GABA-A / drug effects
Receptors, GABA-A / physiology
Stereotyped Behavior / drug effects
Stereotyped Behavior / physiology
Substantia Nigra / drug effects*
Substantia Nigra / physiopathology
gamma-Aminobutyric Acid / physiology*

Substances

Receptors, Dopamine D1
Receptors, Dopamine D2
Receptors, GABA-A
gamma-Aminobutyric Acid
Haloperidol