Pooled human IGG (PHIG) inhibits the binding of anti-myeloperoxidase antibodies to myeloperoxidase

A A Pall; M Varagunam; D Adu; N Smith; C M Taylor; J Michael

doi:10.1007/978-1-4757-9182-2_14

Pooled human IGG (PHIG) inhibits the binding of anti-myeloperoxidase antibodies to myeloperoxidase

Adv Exp Med Biol. 1993:336:93-6. doi: 10.1007/978-1-4757-9182-2_14.

Authors

A A Pall¹, M Varagunam, D Adu, N Smith, C M Taylor, J Michael

Affiliation

¹ Renal Research Laboratories, Queen Elizabeth Hospital, Birmingham.

PMID: 8296681
DOI: 10.1007/978-1-4757-9182-2_14

Abstract

This study demonstrates that pooled human immunoglobulin (PHIG) contains anti-idiotypes to anti-myeloperoxidase (MPO) antibodies and can inhibit the binding of anti-MPO to MPO. The variability seen in the inhibitory effect of different PHIG preparations in the same and also in different patient sera suggests heterogeneity in the idiotypic repertoire of anti-MPO antibodies.

MeSH terms

Antibodies, Anti-Idiotypic / pharmacology*
Autoantibodies / immunology*
Chromatography, Affinity
Humans
Immunoglobulin Fab Fragments / immunology
Immunoglobulin G / pharmacology*
Peroxidase / immunology*
Vasculitis / immunology*

Substances

Antibodies, Anti-Idiotypic
Autoantibodies
Immunoglobulin Fab Fragments
Immunoglobulin G
Peroxidase