Extra medullary plasmocytoma (EMP) is a plasma cell proliferation of low frequency as compared to multiple myeloma which develops in the upper digestive and respiratory tracts and sometimes in the digestive tract. Other sites are possible but pancreatic or hepatic localizations are unusual with few cases being reported in the literature. This study describes an exceptional observation of pancreatic followed by hepatic plasmocytomas occurring after a long evolution of recurrent EMP. A review of the literature shows that the usual forms of treatment are surgery and radiotherapy. In our patient, this was possible for the pancreatic plasmocytoma, whereas the hepatic lesion was first treated with general polychemotherapy because of the tumour size and adverse prognostic factors. Surgery was then followed by recombinant interferon alpha therapy to obtain complete and hopefully prolonged remission.