A 36-year-old male (case-1) and a 54-year-old female (case-2) were admitted to our hospital because of chest oppression on effort. Exercise electrocardiograms of both patients revealed significant ST segment depression in leads II, III, aVF and V5-6. Coronary angiograms demonstrated an anomalous origin of the left circumflex coronary artery in case-1 and an anomalous origin of the right coronary artery in case-2. Furthermore transesophageal echocardiography (TEE) revealed that both anomalous coronary arteries were running from the non-coronary sinus of Valsalva. The anatomical relation between the anomalous coronaries running from non-coronary sinus of valsalva and the great vessels was directly detectable by TEE. Although these cases are very rare, TEE is useful for the assessment of this type of coronary anomaly.