Objectives: To assess the simultaneous variations in blood gases and CO2 tele-expiratory pressure (ETCO2) produced by changes in tissue perfusion in anesthetized patients with stable lung perfusion, alveolar ventilation and metabolic states.
Material and methods: Forty patients were divided into two groups. Group 1 included 20 ASA I patients undergoing orthopedic surgery on the lower extremities. Group 2 included 20 ASA I-III patients undergoing peripheral vascular surgery during which myocardial depression developed after isoflurane administration. The decrease in minute volume was measured in the descending aorta by esophageal ultrasound in both groups. Other hemodynamic parameters were measured by digital plethysmography. ETCO2 was measured by lateral aspiration capnography, and central venous pressure was measured in group 2 by subclavian venous catheter. Measurements were taken before and after release of the tourniquet in group 1, and before and after the decrease in minute volume (> 30%) in group 2.
Results: Release of the tourniquet after a mean compression time of 51 +/- 07 minutes produced an increase of 52% (p < 0.001) in minute volume in all patients in group 1; an increase of 23% (p < 0.001) in ETCO2; and a decrease of 60% (p < 0.001) in total vascular resistance. In group 2 a 15% decrease in ETCO2 (p < 0.01) was observed, coinciding with a 35% decrease in minute volume (p < 0.01).
Conclusions: An increase in minute volume produces an increase in ETCO2 while a decrease in minute volume results in a decrease in ETCO2. This means that sharp changes in ETCO2 may be useful in judging the degree of change in tissue perfusion when other parameters like alveolar ventilation, lung perfusion and metabolic rate remain constant.