Changes in adherence of respiratory pathogens to HEp-2 cells induced by subinhibitory concentrations of sparfloxacin, ciprofloxacin, and trimethoprim

M R Visser; H Beumer; A I Hoepelman; M Rozenberg-Arska; J Verhoef

doi:10.1128/AAC.37.4.885

Changes in adherence of respiratory pathogens to HEp-2 cells induced by subinhibitory concentrations of sparfloxacin, ciprofloxacin, and trimethoprim

Antimicrob Agents Chemother. 1993 Apr;37(4):885-8. doi: 10.1128/AAC.37.4.885.

Authors

M R Visser¹, H Beumer, A I Hoepelman, M Rozenberg-Arska, J Verhoef

Affiliation

¹ Department of Clinical Microbiology, University Hospital Utrecht, The Netherlands.

Abstract

Preincubation with subinhibitory concentrations of sparfloxacin, ciprofloxacin, and trimethoprim decreased the adherence of the respiratory pathogens Klebsiella pneumoniae, Haemophilus influenzae, and Moraxella (Branhamella) catarrhalis to human larynx carcinoma HEp-2 cells. Subinhibitory concentrations of sparfloxacin did not change the adherence of Pseudomonas aeruginosa or Streptococcus pneumoniae 15.62, but adhesion of S. pneumoniae 15.42 was significantly enhanced by subinhibitory antimicrobial concentrations.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / pharmacology*
Bacteria / drug effects*
Bacterial Adhesion / drug effects*
Carcinoma / metabolism
Ciprofloxacin / pharmacology*
Fluoroquinolones*
Humans
Laryngeal Neoplasms / metabolism
Quinolones / pharmacology*
Respiratory Tract Infections / microbiology*
Trimethoprim / pharmacology*
Tumor Cells, Cultured

Substances

Anti-Infective Agents
Fluoroquinolones
Quinolones
Ciprofloxacin
Trimethoprim
sparfloxacin