Abstract
Changes in inositol lipid and diacylglycerol metabolism have been analysed in Daudi lymphoma cells treated up to 24 h with human DNA recombinant interferon alpha. Results showing a different response of nuclear phosphoinositides and diacylglycerol, compared to whole cells, suggest that the intranuclear signalling system activated by interferon in Daudi cells involves nuclear inositol lipid metabolism. A well-characterized clone of Daudi cells selected for resistance to the antiproliferative action of interferon provided controls for the specificity of results.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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B-Lymphocytes / drug effects
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B-Lymphocytes / metabolism*
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Burkitt Lymphoma / metabolism*
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Cell Nucleus / drug effects
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Cell Nucleus / physiology*
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Diglycerides / metabolism
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Down-Regulation
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Drug Resistance
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Humans
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Interferon Type I / pharmacology*
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Male
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Membrane Lipids / metabolism
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Nuclear Envelope / metabolism
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Phosphatidylinositol 4,5-Diphosphate
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Phosphatidylinositols / physiology*
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Phosphorylation
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Recombinant Proteins
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Second Messenger Systems*
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Tumor Cells, Cultured
Substances
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Diglycerides
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Interferon Type I
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Membrane Lipids
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Phosphatidylinositol 4,5-Diphosphate
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Phosphatidylinositols
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Recombinant Proteins