Peripheral expansion of gamma delta T cell receptor-positive cells in a patient with Crohn's disease

T Hara; T Matsumoto; Y Mizuno; M Nishizaki; K Ueda; M Motooka; N Kimura; K Oshimi; S Ohga; Y Yoshikai

doi:10.1111/j.1442-200x.1993.tb03004.x

Peripheral expansion of gamma delta T cell receptor-positive cells in a patient with Crohn's disease

Acta Paediatr Jpn. 1993 Feb;35(1):45-8. doi: 10.1111/j.1442-200x.1993.tb03004.x.

Authors

T Hara¹, T Matsumoto, Y Mizuno, M Nishizaki, K Ueda, M Motooka, N Kimura, K Oshimi, S Ohga, Y Yoshikai

Affiliation

¹ Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

PMID: 8460544
DOI: 10.1111/j.1442-200x.1993.tb03004.x

Abstract

A 13 year old boy with Crohn's disease had a prominent expansion (over 40%) of gamma delta T cell receptor-positive cells (gamma delta T cells) in the peripheral blood. The gamma delta T cells were gradually decreased from 48 to 22% in 18 months. Anti-gamma delta T cell receptor-triggered cytotoxicity was evident at onset and after 1 year. The significance of peripheral expansion of gamma delta T cells in a patient with Crohn's disease is discussed.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Crohn Disease / immunology*
Cytotoxicity, Immunologic*
Flow Cytometry
Humans
Male
Receptors, Antigen, T-Cell, gamma-delta / immunology*

Substances

Receptors, Antigen, T-Cell, gamma-delta