CD46-mediated measles virus entry: a first key to host-range specificity

Trends Microbiol. 1995 Sep;3(9):338-45. doi: 10.1016/s0966-842x(00)88972-6.

Abstract

Humans are the sole natural host of measles virus. The identification of CD46 as a virus receptor and of the involvement of moesin sheds some light on the molecular events occurring during virus entry into the cell. Knowledge of the key role of CD46 paves the way to creating transgenic mice sensitive to measles virus infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD / metabolism*
  • Disease Models, Animal
  • Hemagglutinins, Viral / metabolism*
  • Humans
  • Measles virus / pathogenicity
  • Measles virus / physiology*
  • Measles virus / ultrastructure
  • Membrane Cofactor Protein
  • Membrane Glycoproteins / metabolism*
  • Mice
  • Mice, Transgenic
  • Microfilament Proteins*
  • Proteins / metabolism
  • Species Specificity
  • Viral Fusion Proteins / metabolism
  • Virus Replication

Substances

  • Antigens, CD
  • CD46 protein, human
  • Hemagglutinins, Viral
  • Mcp protein, mouse
  • Membrane Cofactor Protein
  • Membrane Glycoproteins
  • Microfilament Proteins
  • Proteins
  • Viral Fusion Proteins
  • moesin