Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice

Biosci Biotechnol Biochem. 1995 Nov;59(11):2191-2. doi: 10.1271/bbb.59.2191.

Abstract

We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice.

MeSH terms

  • 3-Hydroxyanthranilate 3,4-Dioxygenase
  • Animals
  • Brain / enzymology*
  • Brain / metabolism
  • Dioxygenases*
  • Epilepsy / enzymology*
  • Epilepsy / genetics
  • Genetic Predisposition to Disease
  • Mice
  • Molecular Sequence Data
  • Oxygenases / genetics*
  • Quinolinic Acid / metabolism
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism

Substances

  • RNA, Messenger
  • Oxygenases
  • Dioxygenases
  • 3-Hydroxyanthranilate 3,4-Dioxygenase
  • Quinolinic Acid

Associated data

  • GENBANK/D28339
  • GENBANK/D44494