Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit

FEBS Lett. 1995 Dec 27;377(3):383-9. doi: 10.1016/0014-5793(95)01377-6.

Abstract

A novel potassium channel beta-subunit (Kv beta 3) was cloned from rat brain being the third member of a Kv beta subunit gene family. It is a protein of 403 amino acid residues with a 68% amino acid sequence homology to Kv beta 1.1. Kv beta 3 is primarily expressed in rat brain having a distribution distinct to those of Kv beta 1.1 and Kv beta 2. This subunit also has a long N-terminal structure and induces inactivation in N-terminal deleted Kv1.4 but not in other members of the Kv1 channel family. Similarly to Kv beta 1.1, the Kv beta 3-induced inactivation is regulated by the intracellular redox potential.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / anatomy & histology
  • Brain Chemistry*
  • DNA, Complementary / genetics
  • Electric Conductivity
  • Gene Library
  • Large-Conductance Calcium-Activated Potassium Channel beta Subunits
  • Molecular Sequence Data
  • Multigene Family
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / isolation & purification*
  • Nerve Tissue Proteins / metabolism
  • Oocytes
  • Patch-Clamp Techniques
  • Potassium Channels / genetics
  • Potassium Channels / isolation & purification*
  • Potassium Channels / metabolism
  • Protein Conformation
  • RNA, Messenger / analysis
  • Rats
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Tissue Distribution
  • Xenopus

Substances

  • DNA, Complementary
  • Kcnab3 protein, rat
  • Large-Conductance Calcium-Activated Potassium Channel beta Subunits
  • Nerve Tissue Proteins
  • Potassium Channels
  • RNA, Messenger

Associated data

  • GENBANK/X70662
  • GENBANK/X76723