Orally active squalene synthase inhibitors: bis((acyloxy)alkyl) prodrugs of the alpha-phosphonosulfonic acid moiety

J Med Chem. 1996 Feb 2;39(3):661-4. doi: 10.1021/jm950735s.
No abstract available

MeSH terms

  • Administration, Oral
  • Animals
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Farnesyl-Diphosphate Farnesyltransferase / antagonists & inhibitors*
  • Guinea Pigs
  • Hypolipidemic Agents / chemical synthesis
  • Hypolipidemic Agents / chemistry
  • Hypolipidemic Agents / pharmacology*
  • Prodrugs / chemical synthesis
  • Prodrugs / chemistry
  • Prodrugs / pharmacology*
  • Rats
  • Sulfonic Acids / chemical synthesis
  • Sulfonic Acids / chemistry
  • Sulfonic Acids / pharmacology*

Substances

  • Enzyme Inhibitors
  • Hypolipidemic Agents
  • Prodrugs
  • Sulfonic Acids
  • Farnesyl-Diphosphate Farnesyltransferase