The holmium:YAG laser possesses both ablative and hemostatic properties and in preliminary clinical use has demonstrated many potential urologic applications. We review our initial experience in treating a variety of soft-tissue lesions of the urinary tract with this laser. A total of 51 patients underwent 53 procedures including superficial bladder tumor ablation (25), incision of ureteral stricture (15), incision of urethral stricture (6), relief of ureteropelvic junction obstruction (3), incision of bladder neck contracture (2), and ureteral tumor ablation (2). Procedures were considered successful, with no further intervention or alternative energy source required, in 81% of the cases. The laser demonstrated precise hemostatic cutting and warrants further investigation as a multipurpose urologic laser.