Oligoblastic leukaemia with (8;21) translocation and haemophagocytic syndrome and granulocytic cannibalism

Leuk Res. 1996 Jun;20(6):517-21. doi: 10.1016/0145-2126(95)00157-3.

Abstract

We report a 47-year-old man with oligoblastic leukaemia (8;21) translocation, phenomenon of cannibalism by granulocytic cells and haemophagocytic syndrome. The patient responded to intensive chemotherapy with disappearance of haemophagocytosis, granulocytic and histiocytic. We conclude that: (1) granulocytic cannibalism and haemophagocytic syndrome can be unusual myelodysplastic features; (2) the oligoblastic leukaemia with presence of cytogenetic abnormalities related to AML in young patients are probably more close to acute leukaemia than to myelodysplastic syndrome.

Publication types

  • Case Reports

MeSH terms

  • Chromosomes, Human, Pair 21*
  • Chromosomes, Human, Pair 8*
  • Granulocytes / pathology*
  • Histiocytosis, Non-Langerhans-Cell / complications
  • Histiocytosis, Non-Langerhans-Cell / genetics*
  • Histiocytosis, Non-Langerhans-Cell / pathology
  • Humans
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / pathology
  • Male
  • Middle Aged
  • Translocation, Genetic*