Low incidence of serotonin-induced occlusive coronary artery spasm in patients with recent myocardial infarction

Am J Cardiol. 1996 Jul 1;78(1):84-7. doi: 10.1016/s0002-9149(96)00230-5.

Abstract

Intracoronary infusion of serotonin has been reported to induce varying degrees of coronary vasoconstriction in different coronary syndromes, but it has never been studied in patients after myocardial infarction. In patients with recent myocardial infarction, we found a low incidence (11%) of serotonin-induced occlusive spasm only in the infarct-related artery (IRA), and a significantly higher vasoconstriction in the distal segment of the IRA than in the same segment of the non-IRA.

Publication types

  • Comparative Study

MeSH terms

  • Cardiac Catheterization
  • Coronary Angiography
  • Coronary Vasospasm / physiopathology*
  • Coronary Vessels / drug effects
  • Coronary Vessels / physiopathology
  • Female
  • Humans
  • Infusions, Intra-Arterial
  • Isosorbide Dinitrate / administration & dosage
  • Isosorbide Dinitrate / pharmacology
  • Male
  • Middle Aged
  • Myocardial Infarction / physiopathology*
  • Serotonin / administration & dosage
  • Serotonin / pharmacology*
  • Vasoconstriction / drug effects
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / pharmacology

Substances

  • Vasodilator Agents
  • Serotonin
  • Isosorbide Dinitrate