Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

C Nilsson; G Karlsson; K Blennow; M Heilig; R Ekman

doi:10.1016/0196-9781(96)00013-7

Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

Peptides. 1996;17(3):359-62. doi: 10.1016/0196-9781(96)00013-7.

Authors

C Nilsson¹, G Karlsson, K Blennow, M Heilig, R Ekman

Affiliation

¹ Department of Neurochemistry, University of Göteborg, Mölndal, Sweden.

PMID: 8735959
DOI: 10.1016/0196-9781(96)00013-7

Abstract

In this study, patients with recurrent major depression were found to have significantly lower neuropeptide Y-like immunoreactivity (NPY-LI) in platelet-poor plasma (p < 0.01) and significantly higher NPY-LI in platelets (p < 0.001) compared to controls. Also, qualitative differences in the NPY-LI in platelet-poor plasma (PPP) and platelets were detected when the samples were analyzed by HPLC followed by RIA of the collected fractions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Blood Platelets / chemistry*
Chromatography, High Pressure Liquid
Depression / blood*
Female
Humans
Male
Middle Aged
Neuropeptide Y / blood*
Neuropeptide Y / immunology
Radioimmunoassay

Substances

Neuropeptide Y