Abstract
A study of Sinularia gardineri (Pratt) (Alcyoniidae), collected in the Red Sea, revealed a new heptacyclic norcembranoid dimer singardin (1). The structure of singardin was deduced by spectroscopic analysis. A known sesquiterpene, guaianediol (2), and the known cembranolides (1R,5S,8R,10S,11R)-11-hydroxy-1-isoprenyl-8-methyl-3,6-dioxo -5,8-epoxycyclotetradec-12-ene 10,12-carbolactone (5-epi-sinuleptolide) and sinuleptolide were also isolated. Compounds 1 and 2 show cytotoxicity to murine leukemia (P-388), human lung carcinoma (A-549), human colon carcinoma (HT-29), and human melanoma cells (MEL-28).
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antifungal Agents / pharmacology
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Candida albicans / drug effects
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Cnidaria / chemistry*
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Cryptococcus neoformans / drug effects
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Drug Screening Assays, Antitumor
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Furans / isolation & purification*
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Furans / pharmacology
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Humans
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Lactones / isolation & purification*
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Lactones / pharmacology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Spectrophotometry, Infrared
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Tumor Cells, Cultured
Substances
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Antifungal Agents
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Antineoplastic Agents
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Furans
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Lactones
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singardin