Abstract
A series of 1,2-dihydro-4-phenylquinolin-2-one-3-carboxylic acid and of 3-amino-4-phenylcarbostyril derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-A rather than CCK-B receptor and the results have been discussed on the basis of a molecular modelling study.
MeSH terms
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Animals
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Cerebral Cortex / metabolism
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Chemical Phenomena
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Chemistry, Physical
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Guinea Pigs
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Mass Spectrometry
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Models, Molecular
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Pancreas / metabolism
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Quinolones / chemical synthesis*
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Quinolones / chemistry
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Quinolones / pharmacokinetics
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Radioligand Assay
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Rats
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Rats, Wistar
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Receptors, Cholecystokinin / drug effects
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Receptors, Cholecystokinin / metabolism*
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Quinolones
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Receptors, Cholecystokinin