[Effects of fluorescein and indocyanine green angiography on subsequent dark adaptation and the electroretinogram]

Klin Monbl Augenheilkd. 1996 Apr;208(4):224-8. doi: 10.1055/s-2008-1035200.
[Article in German]

Abstract

Background: In clinical practice the electroretinogram (ERG) usually should not be recorded immediately after conventional fluorescein angiography (FLA), because of the bleaching effects of strong light exposure on the course of dark adaptation and on the ERG. Currently it is not known, if indocyaningreen (ICG) angiography using the Heidelberg Retina Angiograph (HRA) has similar effects on the outer retina and if therefore the ERG should also not be recorded after ICG angiography.

Methods: Eight patients with different retinal diseases were examined. After 5 minutes of light adaptation to 160 cd/m2, Ganzfeld ERGs were repeatedly recorded using DTL electrodes during a 30 minutes dark period with a flash luminance of 0.1 cds/.m2. After this dark adaptation period a standardized ERG was recorded according to the ISCEV recommendations. This procedure was followed either by ICG angiography using the HRA or by conventional fluorescein angiography using the Canon CF 60 fundus camera. Within an interval of 5 minutes the above mentioned ERG procedure was repeated.

Results: ICG angiography using the HRA did neither affect the course of dark adaptation as measured by increasing b-wave amplitudes during the 30 minutes dark adaptation period, nor the values for each response of the Ganzfeld standard ERG. FLA did neither affect b-wave responses to dim stimuli, nor to stronger stimuli in the scotopic range. However, the course of dark adaptation was significantly prolonged after FLA. The maximum b-wave was not affected.

Conclusions: ICG angiography using the HRA could be performed prior to the recording of the ERG, without any effect on the ERG. In contrast conventional FLA must be performed after ERG recordings, in order not to alter the electrophysiological responses.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adult
  • Angiography*
  • Child, Preschool
  • Coloring Agents*
  • Dark Adaptation / drug effects*
  • Dark Adaptation / physiology
  • Electroretinography / drug effects*
  • Female
  • Humans
  • Indocyanine Green*
  • Macular Degeneration / diagnosis*
  • Macular Degeneration / physiopathology
  • Male
  • Middle Aged
  • Reference Values
  • Retinal Diseases / diagnosis*
  • Retinal Diseases / physiopathology

Substances

  • Coloring Agents
  • Indocyanine Green