IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells

FEBS Lett. 1996 Sep 9;393(1):53-6. doi: 10.1016/0014-5793(96)00835-6.

Abstract

IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4R alpha and IL2R gamma c are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / chemistry
  • Antigens, CD / metabolism*
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism*
  • Child
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Immunoglobulin Constant Regions / immunology
  • Immunoglobulin gamma-Chains / immunology
  • Interleukin-13 / metabolism
  • Interleukin-13 Receptor alpha1 Subunit
  • Interleukin-4 / metabolism
  • Janus Kinase 1
  • Janus Kinase 3
  • Milk Proteins*
  • Phosphorylation
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Interleukin / chemistry
  • Receptors, Interleukin / metabolism*
  • Receptors, Interleukin-13
  • Receptors, Interleukin-2 / immunology
  • Receptors, Interleukin-4
  • Recombinant Proteins / metabolism
  • STAT3 Transcription Factor
  • STAT5 Transcription Factor
  • STAT6 Transcription Factor
  • Time Factors
  • Trans-Activators / metabolism*
  • Tyrosine / metabolism

Substances

  • Antigens, CD
  • DNA-Binding Proteins
  • IL13RA1 protein, human
  • Immunoglobulin Constant Regions
  • Immunoglobulin gamma-Chains
  • Interleukin-13
  • Interleukin-13 Receptor alpha1 Subunit
  • Milk Proteins
  • Receptors, Interleukin
  • Receptors, Interleukin-13
  • Receptors, Interleukin-2
  • Receptors, Interleukin-4
  • Recombinant Proteins
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • STAT5 Transcription Factor
  • STAT6 Transcription Factor
  • STAT6 protein, human
  • Trans-Activators
  • Interleukin-4
  • Tyrosine
  • Protein-Tyrosine Kinases
  • JAK1 protein, human
  • JAK3 protein, human
  • Janus Kinase 1
  • Janus Kinase 3