The effects of n-3 and n-6 polyunsaturated fatty acids on plasma lipids and fatty acids of treated phenylketonuric children

Prostaglandins Leukot Essent Fatty Acids. 1995 Dec;53(6):401-4. doi: 10.1016/0952-3278(95)90103-5.

Abstract

Dietary-treated phenylketonuric patients (PKUs) display low levels of long-chain polyunsaturated fatty acids (PUFA) in plasma lipids. In a 6-month clinical trial we observed a decrease of triglycerides and an increase of n-3 long-chain PUFA in plasma of PKUs supplemented with fish oil, while no major differences in respect to the baseline values were found in a group supplemented with blackcurrant oil. A more complete source of long-chain PUFA of both the n-6 and n-3 series should be investigated for dietary supplementation of PKU patients.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Dietary Fats, Unsaturated / administration & dosage*
  • Fatty Acids / blood*
  • Fatty Acids, Omega-3 / administration & dosage*
  • Fatty Acids, Omega-6
  • Fatty Acids, Unsaturated / administration & dosage*
  • Female
  • Fish Oils / administration & dosage*
  • Humans
  • Lipids / blood*
  • Male
  • Phenylketonurias / blood*
  • Phenylketonurias / diet therapy
  • Triglycerides / blood

Substances

  • Dietary Fats, Unsaturated
  • Fatty Acids
  • Fatty Acids, Omega-3
  • Fatty Acids, Omega-6
  • Fatty Acids, Unsaturated
  • Fish Oils
  • Lipids
  • Triglycerides