Regulation of Epstein-Barr virus latency by latent membrane protein 2

Trends Microbiol. 1996 Jan;4(1):38-42. doi: 10.1016/0966-842x(96)81504-6.

Abstract

Like other herpesviruses, Epstein-Barr virus persists in its host through its ability to establish a latent infection that periodically reactivates. Latent membrane protein 2A (LMP2A) regulates reactivation from latency by interfering with normal B cell signal transduction processes, and may define a new class of regulators of herpesvirus latency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • B-Lymphocytes / immunology*
  • Gene Expression Regulation, Viral
  • Genes, Viral / genetics*
  • Herpesviridae Infections / immunology*
  • Herpesviridae Infections / virology*
  • Herpesvirus 4, Human / immunology*
  • Herpesvirus 4, Human / physiology
  • Humans
  • Molecular Sequence Data
  • Signal Transduction
  • Viral Matrix Proteins / genetics
  • Viral Matrix Proteins / immunology*
  • Virus Latency / physiology*

Substances

  • EBV-associated membrane antigen, Epstein-Barr virus
  • Viral Matrix Proteins