Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus

Genomics. 1996 Jan 15;31(2):246-9. doi: 10.1006/geno.1996.0041.

Abstract

A cDNA encoding the rat endopeptidase 24.15 was used to determine the chromosomal localization of the respective human gene. Hybridization to DNA from human-rodent somatic cell hybrids assigned the human gene to chromosome 19. Fluorescence in situ hybridization on human metaphase chromosomes localized the human endopeptidase 24.15 to 19q13.3.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alzheimer Disease / genetics
  • Animals
  • Chromosomes, Human, Pair 19 / genetics*
  • Endopeptidases / genetics*
  • Genome, Human
  • Humans
  • Rats

Substances

  • Endopeptidases