Significant progress has been made in the field of cancer metastasis, and the molecular mechanism of cancer metastasis is being studied extensively. Recent studies revealed that some oncogenes and metastasis-associated genes play important roles in cancer metastasis. Some nuclear transcription factors have appeared to be involved in this metastasis. Ets-related E1AF confers the invasive phenotype on cancer cells. E1AF that acts as a transcription factor is believed to play an important role in cancer invasiveness/metastasis through transcriptions of metastasis-related genes.