Abstract
Spinal cord compression as first presentation of non-Hodgkin's lymphoma (NHL) is an uncommon event. Diagnosis of NHL usually is performed on a laminectomy specimen. Spinal cord compression has been reported in 5% of patients with solid tumors. Although this clinical picture has been considered as very unusual among NHL patients, some series regarding descompresive laminectomy indicate that NHL was the underlying cause in 15% of these cases. We report two cases of patients with NHL who presented paraparesia secondary to spinal cord compression due to lymphomatous mass in the epidural region which was showed by magnetic resonance imaging. The emergency laminectomy and treatment with chemotherapy allowed the clinical recuperation of both patients.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Epidural Space
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Etoposide / administration & dosage
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Female
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Humans
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Laminectomy
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Leucovorin / administration & dosage
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Leukemia, Lymphocytic, Chronic, B-Cell / complications*
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Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis
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Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
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Leukemia, Lymphocytic, Chronic, B-Cell / surgery
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Lymphoma, Large B-Cell, Diffuse / complications*
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Lymphoma, Large B-Cell, Diffuse / diagnosis
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Lymphoma, Large B-Cell, Diffuse / drug therapy
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Lymphoma, Large B-Cell, Diffuse / surgery
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Mechlorethamine / administration & dosage
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Methotrexate / administration & dosage
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Middle Aged
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Paresis / etiology
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Paresthesia / etiology
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Prednisone / administration & dosage
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Procarbazine / administration & dosage
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Soft Tissue Neoplasms / complications*
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Soft Tissue Neoplasms / diagnosis
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Soft Tissue Neoplasms / drug therapy
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Soft Tissue Neoplasms / surgery
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Spinal Cord Compression / etiology*
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Spinal Cord Compression / surgery
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Spinal Neoplasms / complications*
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Spinal Neoplasms / diagnosis
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Spinal Neoplasms / drug therapy
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Spinal Neoplasms / surgery
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Thoracic Neoplasms / complications*
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Thoracic Neoplasms / diagnosis
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Thoracic Neoplasms / drug therapy
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Thoracic Neoplasms / surgery
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Thoracic Vertebrae*
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Urinary Retention / etiology
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Vincristine / administration & dosage
Substances
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Procarbazine
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Mechlorethamine
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Vincristine
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Etoposide
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Doxorubicin
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Cyclophosphamide
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Leucovorin
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Prednisone
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Methotrexate
Supplementary concepts
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CHOP protocol
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MOPP protocol
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PROMACE protocol