Characterization of the feline herpesvirus type 1 immediate early gene expression

J Vet Med Sci. 1996 Aug;58(8):715-21. doi: 10.1292/jvms.58.715.

Abstract

We analyzed the mechanism for feline herpesvirus type 1 (FHV-1) immediate early (IE) gene expression. We demonstrated that (i) the transcription initiation site of the FHV-1 IE transcript lies in the putative FHV-1 ICP4 binding site, (ii) the FHV-1 IE transcript is spliced to remove 906 bp intron from the leader region, (iii) cis-acting elements of the FHV-1 IE promoter map both down- and upstream of the transcription initiation site, and (iv) a deletion of a 58 bp sequence which includes the putative FHV-1 ICP4 binding site in the IE promoter resulted in significant induction of promoter activity by a FHV-1 IE gene product although the FHV-1 IE gene product slightly stimulates the FHV-1 IE promoter, indicating that the FHV-1 IE gene product down-regulates its own promoter via the region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alphaherpesvirinae / genetics*
  • Alphaherpesvirinae / metabolism*
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cats
  • Cell Line
  • Chloramphenicol O-Acetyltransferase / biosynthesis
  • DNA Primers
  • Gene Expression Regulation, Viral*
  • Genes, Immediate-Early*
  • Immediate-Early Proteins / biosynthesis*
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Promoter Regions, Genetic
  • Recombinant Proteins / biosynthesis
  • Regulatory Sequences, Nucleic Acid
  • Transcription, Genetic
  • Transfection

Substances

  • DNA Primers
  • Immediate-Early Proteins
  • Recombinant Proteins
  • Chloramphenicol O-Acetyltransferase