The economic crisis has led to the onset of resurgence of several infectious diseases among patients with social deprivation. Health access being difficult for these patients, delay between onset of symptoms and time of diagnosis is increased and therapeutic adherence is impaired. Such conditions favour the transmission of infectious agents via either direct human interaction (sexual and blood transmission) or arthropode-borne agents. Tuberculosis remains the most frequent infection observed in this population and appears as a major public health problem. Such diseases underline the need for global approach of the patient, including a search for infected contact of sufficient duration, treatments and prevention of recurrence.