The elastic limit of bone surrounding implants may be surpassed and thus produce microfractures in bone. The purpose of this study was to use computer simulations to examine clinical situations with IMZ implants in edentulous mandibles and to identify loading conditions that could lead to bone microfractures. Three-dimensional finite element analysis models were used to examine effects of: (1) types of edentulous mandibles, (2) veneering materials, (3) the absence of cortical bone, (4) different intramobile elements, (5) loading directions, and (6) loading levels. Stress distribution patterns were compared and interfacial stresses were monitored specifically at four heights along the bone-implant interface. Stresses were concentrated toward cortical bone (0.8 to 15.0 MPa). There were no differences between types of veneering materials and the absence of cortical bone increased interfacial stresses. The use of a titanium intramobile element decreased stresses. Minor stress increases were associated with smaller mandibles. Oblique loads increased stresses 15 times, and 200 N loads increased stresses 10 times. Conditions for bone microfracturing were associated with oblique loads, high occlusal stress magnitudes, and the absence of cortical bone.