99mTechnetium-stannous oxinate as marker of liposome formulations

Nucl Med Biol. 1996 Oct;23(7):881-7. doi: 10.1016/s0969-8051(96)00118-7.

Abstract

Liposomes associated with tin(II) dioxinate were prepared from egg yolk phosphatidylcholine and cholesterol as sterile and pyrogen-free multilamellar or unilamellar vesicles. Complexing of liposomal tin(II) dioxinate with 99mTc attained 98% of the added radioactivity. Thirty percent 99mTc were released during 24-h incubation in biological fluids. The absence of tin colloids seen by electron microscopy and the stability of liposomal phospholipid and tin(II) dioxinate during 72-h incubation at 37 degrees C in plasma and cerebrospinal fluid would allow safe and reliable scintigraphic liposome pharmacokinetic studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cholesterol
  • Colloids
  • Dioxanes
  • Drug Carriers
  • Freeze Etching
  • Humans
  • Liposomes*
  • Lysophosphatidylcholines
  • Microscopy, Electron
  • Organotechnetium Compounds / administration & dosage
  • Organotechnetium Compounds / chemistry*
  • Organotechnetium Compounds / pharmacokinetics
  • Organotin Compounds / administration & dosage
  • Organotin Compounds / chemistry*
  • Organotin Compounds / pharmacokinetics
  • Phosphatidylcholines
  • Radionuclide Imaging
  • Reproducibility of Results
  • Time Factors

Substances

  • Colloids
  • Dioxanes
  • Drug Carriers
  • Liposomes
  • Lysophosphatidylcholines
  • Organotechnetium Compounds
  • Organotin Compounds
  • Phosphatidylcholines
  • technetium Tc 99m stannous oxinate
  • tin(II) dioxinate
  • Cholesterol