Abstract
The new homoisoflavanone R(-)-3-(4-hydroxybenzyl)-5-hydroxy-6, 7,8-trimethoxychroman-4-one (1) was isolated from the petroleum ether and the diethyl ether extracts of the bulbs of Veltheimia viridifolia (Hyacinthaceae) together with the known homoisoflavanone muscomin (2). The structures of the compounds were elucidated by means of 1H-NMR, 2D 1H-1H-COSY, 13C-NMR, HMQC, HMBC, mass, and CD spectra. Pharmacological testings of the new homoisoflavanone are reported.
MeSH terms
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Animals
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology
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Bronchodilator Agents / chemistry
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Bronchodilator Agents / isolation & purification
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Bronchodilator Agents / pharmacology
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Cattle
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Guinea Pigs
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Heart / drug effects
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Humans
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In Vitro Techniques
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Isoflavones / chemistry
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Isoflavones / isolation & purification*
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Isoflavones / pharmacology
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Leukocytes, Mononuclear / drug effects
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Leukotrienes / biosynthesis
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Molecular Structure
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Phosphodiesterase Inhibitors / chemistry
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Phosphodiesterase Inhibitors / isolation & purification
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Phosphodiesterase Inhibitors / pharmacology
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Plants / chemistry*
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South Africa
Substances
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3-(4-hydroxybenzyl)-5-hydroxy-6,7,8-trimethoxychroman-4-one
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Antioxidants
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Bronchodilator Agents
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Isoflavones
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Leukotrienes
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Phosphodiesterase Inhibitors
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muscomin