Recognition of telomeric DNA

Trends Biochem Sci. 1997 Feb;22(2):43-7. doi: 10.1016/s0968-0004(97)01008-6.

Abstract

The three-dimensional structure of the yeast telomere-binding protein RAP1 in complex with DNA provides the first insight into telomeric DNA recognition. RAP1 binds to DNA via two Myb/homeodomain-like motifs, which are DNA-binding folds previously identified in transcription factors. This, together with the finding that human TRF1 and other telomere-binding factors contain Myb-like motifs, has led us to speculate that a conserved protein fold might be used for telomeric DNA recognition.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA / metabolism*
  • DNA, Fungal / genetics
  • DNA, Fungal / metabolism
  • Fungal Proteins / chemistry
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • GTP-Binding Proteins / chemistry
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / metabolism
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Sequence Homology, Amino Acid
  • Telomere / metabolism*
  • rap GTP-Binding Proteins

Substances

  • DNA, Fungal
  • Fungal Proteins
  • DNA
  • GTP-Binding Proteins
  • rap GTP-Binding Proteins