Deep halothane anaesthesia compared with halothane-suxamethonium anaesthesia for tracheal intubation in young children

Eur J Anaesthesiol. 1997 Jan;14(1):29-34. doi: 10.1046/j.1365-2346.1997.00070.x.

Abstract

A double-blind and randomized study design was used to investigate 100 healthy children, aged 1-5 years. Intubating conditions and cardiovascular changes during deep halothane anaesthesia, defined as an end-tidal concentration of 2%, were compared with those changes during 1% halothane and suxamethonium relaxation. Intubating conditions were graded according to the ease of laryngoscopy, vocal cord position, coughing and jaw relaxation. In each group 96% of the children demonstrated acceptable intubating conditions. Jaw relaxation was worse in the 1% halothane/-suxamethonium group (P < 0.01). When anaesthesia with 2% or 1% halothane was compared there was a more pronounced decrease in systolic blood pressure (18 vs. 8%, P < 0.001). Junctional rhythm occurred more frequently during deep halothane anaesthesia (46 vs. 18%, P < 0.01). Intravenously (i.v.) administered atropine attenuated blood pressure depression significantly and reinstituted sinus rhythm in most cases.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Anesthesia, Inhalation*
  • Anesthetics, Inhalation*
  • Blood Pressure / drug effects
  • Child, Preschool
  • Double-Blind Method
  • Female
  • Halothane*
  • Heart Rate / drug effects
  • Humans
  • Infant
  • Intubation, Intratracheal*
  • Male
  • Muscle Relaxation / drug effects
  • Neuromuscular Depolarizing Agents*
  • Succinylcholine*

Substances

  • Anesthetics, Inhalation
  • Neuromuscular Depolarizing Agents
  • Succinylcholine
  • Halothane