Thiopurine biology and pharmacology

Trends Pharmacol Sci. 1997 Jan;18(1):3-7. doi: 10.1016/s0165-6147(96)01007-3.
No abstract available

Publication types

  • Congress

MeSH terms

  • Animals
  • Antimetabolites, Antineoplastic / metabolism
  • Antimetabolites, Antineoplastic / pharmacology
  • Antimetabolites, Antineoplastic / therapeutic use
  • Azathioprine / chemistry
  • Azathioprine / metabolism
  • Azathioprine / pharmacology
  • Cloning, Molecular
  • Genotype
  • Humans
  • Immunosuppressive Agents / chemistry
  • Immunosuppressive Agents / metabolism
  • Immunosuppressive Agents / pharmacology
  • Mercaptopurine / metabolism
  • Mercaptopurine / pharmacology
  • Mercaptopurine / therapeutic use
  • Methyltransferases / deficiency
  • Methyltransferases / genetics*
  • Methyltransferases / metabolism
  • Mice
  • Polymorphism, Genetic / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Purines / chemistry
  • Purines / metabolism*
  • Structure-Activity Relationship
  • Thioguanine / metabolism
  • Thioguanine / pharmacology
  • Thioguanine / therapeutic use

Substances

  • Antimetabolites, Antineoplastic
  • Immunosuppressive Agents
  • Purines
  • Mercaptopurine
  • Methyltransferases
  • thiopurine methyltransferase
  • Thioguanine
  • Azathioprine