Structural correlates of cognition in dementia: quantification and assessment of synapse change

Neurodegeneration. 1996 Dec;5(4):417-21. doi: 10.1006/neur.1996.0056.

Abstract

Dementia results from a combination of structural and neurochemical pathologies. The most reliable index of cognition in both postmortem and biopsied AD brain is synapse loss.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology*
  • Alzheimer Disease / psychology*
  • Cognition*
  • Dentate Gyrus / pathology
  • Enzyme-Linked Immunosorbent Assay
  • Frontal Lobe / pathology
  • Humans
  • Synapses / ultrastructure*
  • Synaptophysin / metabolism
  • Temporal Lobe / pathology

Substances

  • Synaptophysin