Regulation of rat neuronal nitric oxide synthase activity by chronic alcoholization

Alcohol Alcohol. 1997 Jan-Feb;32(1):13-7. doi: 10.1093/oxfordjournals.alcalc.a008228.

Abstract

Rat neuronal nitric oxide (NO) synthase (nNOS) activity was measured in frontal cortex, hippocampus, striatum and cerebellum using the assay of [3H]citrulline, following chronic alcoholization. The Km and Vmax values were significantly increased in the frontal cortex and in the striatum, and were not affected in the cerebellum and hippocampus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcoholism / enzymology*
  • Animals
  • Brain / enzymology*
  • Brain Mapping
  • Corpus Striatum / enzymology
  • Enzyme Induction / drug effects
  • Ethanol / toxicity
  • Frontal Lobe / enzymology
  • Male
  • Neurons / enzymology
  • Nitric Oxide Synthase / metabolism*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Ethanol
  • Nitric Oxide Synthase