Abstract
Rat neuronal nitric oxide (NO) synthase (nNOS) activity was measured in frontal cortex, hippocampus, striatum and cerebellum using the assay of [3H]citrulline, following chronic alcoholization. The Km and Vmax values were significantly increased in the frontal cortex and in the striatum, and were not affected in the cerebellum and hippocampus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcoholism / enzymology*
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Animals
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Brain / enzymology*
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Brain Mapping
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Corpus Striatum / enzymology
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Enzyme Induction / drug effects
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Ethanol / toxicity
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Frontal Lobe / enzymology
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Male
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Neurons / enzymology
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Nitric Oxide Synthase / metabolism*
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Rats
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Rats, Sprague-Dawley
Substances
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Ethanol
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Nitric Oxide Synthase