Abstract
Previously, we tagged a macrophage-induced Salmonella typhimurium locus with Mudlux (K. P. Francis and M. P. Gallagher, Infect. Immun. 61:640-649, 1993). The insertion lies within the OxyR-regulated ahpC locus and conveys alkyl peroxide sensitivity. Plasmid-encoded ahp reverses sensitivity but reduces luminescence. This suggests that OxyR is titrated by the multicopy ahp promoter.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromosome Mapping
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DNA-Binding Proteins*
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Hydrogen Peroxide / pharmacology
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Macrophages / physiology*
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Operon*
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Oxidoreductases / genetics*
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Peroxidases*
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Peroxiredoxins
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Repressor Proteins / genetics
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Salmonella typhimurium / genetics*
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Transcription Factors / genetics
Substances
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DNA-Binding Proteins
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Repressor Proteins
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Transcription Factors
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Hydrogen Peroxide
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Oxidoreductases
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Peroxidases
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Peroxiredoxins