Abstract
Phytochemical analyses of Geigeria alata (Benth. & Hook.) and Francoeuria crispa (Forssk., Cas.) (Asteraceae) essential oils were performed. G. alata oil showed moderate in vitro cytotoxicity (IC50, micrograms/ml against tumor cells; P388: 2.0, A-549: 2.5 and HT-29: 5.0), and also showed weak anti-HIV activity. S-Carvotanacetone, the major component of F. crispa oil (93.0%), was isolated and its structure was elucidated by 2D-NMR analysis.
Publication types
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Letter
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / toxicity
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Cell Survival / drug effects
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Gas Chromatography-Mass Spectrometry
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HIV / drug effects
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HIV / physiology*
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Humans
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Leukemia P388
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Mice
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Oils, Volatile / analysis*
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Plants, Medicinal*
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Plants, Toxic*
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Tumor Cells, Cultured
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Virus Replication / drug effects
Substances
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Anti-HIV Agents
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Antineoplastic Agents, Phytogenic
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Oils, Volatile