Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide

MeSH terms

• Acetamides / chemical synthesis*
• Acetamides / pharmacology*
• Administration, Oral
• Animals
• Anti-Arrhythmia Agents / chemical synthesis*
• Anti-Arrhythmia Agents / pharmacology*
• Benzodiazepinones / chemical synthesis*
• Benzodiazepinones / pharmacology*
• Cells, Cultured
• Dogs
• Electrocardiography, Ambulatory / drug effects
• Guinea Pigs
• Heart / drug effects*
• Heart / physiology
• Humans
• Myocardium / cytology
• Potassium Channel Blockers*
• Potassium Channels / physiology
• Xenopus