Abstract
Plasmodium falciparum antigens SERP, HRPII, MSAI, and 41-3 have shown promise as vaccine components. This study aimed at reproducing and extending previous results using three hybrid molecules. Antibody responses were reproduced in Aotus monkeys, but solid protection from a P. falciparum blood-stage challenge that showed an unintendedly enhanced pathogenicity was not observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Protozoan / biosynthesis*
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Antibodies, Protozoan / immunology
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Antigens, Protozoan / genetics
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Antigens, Protozoan / immunology
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Aotidae
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Malaria, Falciparum / immunology*
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Malaria, Falciparum / prevention & control*
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Plasmodium falciparum / genetics
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Plasmodium falciparum / immunology*
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Protozoan Proteins / immunology*
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Protozoan Vaccines
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Recombinant Proteins / immunology*
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Vaccination
Substances
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Antibodies, Protozoan
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Antigens, Protozoan
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Protozoan Proteins
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Protozoan Vaccines
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Recombinant Proteins
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serine repeat antigen, Plasmodium