Immunization of Aotus monkeys with recombinant Plasmodium falciparum hybrid proteins does not reproducibly result in protection from malaria infection

Infect Immun. 1998 Jan;66(1):373-5. doi: 10.1128/IAI.66.1.373-375.1998.

Abstract

Plasmodium falciparum antigens SERP, HRPII, MSAI, and 41-3 have shown promise as vaccine components. This study aimed at reproducing and extending previous results using three hybrid molecules. Antibody responses were reproduced in Aotus monkeys, but solid protection from a P. falciparum blood-stage challenge that showed an unintendedly enhanced pathogenicity was not observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Protozoan / biosynthesis*
  • Antibodies, Protozoan / immunology
  • Antigens, Protozoan / genetics
  • Antigens, Protozoan / immunology
  • Aotidae
  • Malaria, Falciparum / immunology*
  • Malaria, Falciparum / prevention & control*
  • Plasmodium falciparum / genetics
  • Plasmodium falciparum / immunology*
  • Protozoan Proteins / immunology*
  • Protozoan Vaccines
  • Recombinant Proteins / immunology*
  • Vaccination

Substances

  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Protozoan Proteins
  • Protozoan Vaccines
  • Recombinant Proteins
  • serine repeat antigen, Plasmodium