Neurotrophins in cerebellar granule cell development and medulloblastoma

J Neurooncol. 1997 Dec;35(3):347-52. doi: 10.1023/a:1005841206252.

Abstract

Medulloblastomas may be derived from granule cells of the developing cerebellum. Children with tumors expressing high levels of the neurotrophin-3 receptor, TrkC, have a more favorable outcome. During development, TrkC is expressed in the most mature granule cells. Favorable medulloblastomas may be derived from more highly differentiated granule cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Cerebellar Neoplasms / genetics
  • Cerebellar Neoplasms / pathology
  • Cerebellar Neoplasms / physiopathology*
  • Cerebellum / cytology*
  • Cerebellum / growth & development*
  • Cytoplasmic Granules / drug effects
  • Humans
  • Medulloblastoma / genetics
  • Medulloblastoma / pathology
  • Medulloblastoma / physiopathology*
  • Nerve Growth Factors / physiology*
  • Proto-Oncogene Proteins / biosynthesis
  • Proto-Oncogene Proteins / genetics
  • Receptor Protein-Tyrosine Kinases / biosynthesis
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptor, trkA
  • Receptors, Nerve Growth Factor / biosynthesis
  • Receptors, Nerve Growth Factor / genetics

Substances

  • Nerve Growth Factors
  • Proto-Oncogene Proteins
  • Receptors, Nerve Growth Factor
  • Receptor Protein-Tyrosine Kinases
  • Receptor, trkA