Abstract
Two examples of IgM lambda cold agglutinins (CA) with a new specificity are characterized. 1. CAs ZI and BR react with newborn as well as with adult red cells. 2. Both CAs react with I- and i-active animal red cells. 3. The CAs are inhibited by linear and branched type 2 chains. 4. Endo-beta-galactosidase, splitting type 2 chains from human red cells, abolishes reactivity of both CAs. Both CAs recognize linear as well as branched type 2 chains.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Agglutinins / immunology*
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Animals
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Antibody Specificity
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Autoantibodies / blood*
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Cryoglobulins
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Erythrocytes / immunology*
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Glycoside Hydrolases*
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Humans
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Immunoglobulin M / blood*
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Infant, Newborn
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Male
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Middle Aged
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Waldenstrom Macroglobulinemia / blood*
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Waldenstrom Macroglobulinemia / immunology
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beta-Galactosidase
Substances
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Agglutinins
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Autoantibodies
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Cryoglobulins
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Immunoglobulin M
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cold agglutinins
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Glycoside Hydrolases
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keratan-sulfate endo-1,4-beta-galactosidase
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beta-Galactosidase