Coronary angioplasty of chronic total occlusions has been limited by a relatively low success rate and a high average restenosis rate of 53%. We prospectively assessed the immediate and long-term outcome of primary stenting after performing successful recanalization of chronic total occlusions in 38 consecutive patients. Thirty-three men and five women (mean age 56+/-11 years) in whom 39 total occlusions were stented with a successful stent delivery of 97% were evaluated. After stent deployment quantitative angiography demonstrated the mean reference diameter to be 3.42+/-0.44 mm with a mean residual stenosis of 6%+/-9%. Immediately after the stent was implanted, no major complications occurred. Patients underwent clinical and angiographic follow-up at a mean of 6+/-1 months after stent implantation. At 6 months after stent implantation 74% of the patients had no symptoms and remained free of death, myocardial infarction, or target lesion revascularization. Quantitative follow-up angiography was performed in 90% of the patients. The angiographic restenosis rate (>50% diameter stenosis) was 40% (14 of 35 lesions). In eight (23%) of these lesions a reocclusion was noted. Repeat uneventful angioplasty was performed in five (14%) patients with symptomatic restenosis at the stent site, and two (5%) patients had elective coronary artery bypass graft surgery. In conclusion, intracoronary stent implantation is a safe and effective technique in patients with chronic total coronary occlusions. The angiographic restenosis rate of 40% after stenting compares favorably with that in historical balloon angioplasty control series. However, further improvement of this technique is required to reduce the relatively high restenosis rate in patients with chronic total occlusions.