Abstract
Ninety-four GB virus C/hepatitis G virus (GBV-C/ HGV) RNA-positive serum samples were obtained from all over the world. We found that all 15 GBV-C/HGV isolates from the Pygmies and the Bantu in the Central African region had a 12-amino acid indel (i.e. insertion or deletion) in the non-structural protein (NS) 5A region. Phylogenetic analyses of the NS5A region, using GBV-A as an outgroup, showed that these 15 isolates had diverged from the common ancestor much earlier than the remaining isolates, indicating an African origin of GBV-C/HGV.
MeSH terms
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Africa
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Amino Acid Sequence
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Flaviviridae / chemistry*
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Flaviviridae / genetics
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Genotype
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Humans
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Molecular Sequence Data
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Phylogeny
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RNA Helicases
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RNA, Viral / chemistry*
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Sequence Alignment
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Sequence Homology, Amino Acid
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Serine Endopeptidases
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Viral Nonstructural Proteins / genetics*
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Viral Proteins / chemistry*
Substances
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NS3 protein, flavivirus
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NS5 protein, flavivirus
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RNA, Viral
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Viral Nonstructural Proteins
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Viral Proteins
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Serine Endopeptidases
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RNA Helicases
Associated data
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GENBANK/AB010155
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GENBANK/AB010156
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GENBANK/AB010157
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GENBANK/AB010158
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GENBANK/AB010159
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GENBANK/AB010160
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GENBANK/AB010161
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GENBANK/AB010162
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GENBANK/AB010163
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GENBANK/AB010164
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GENBANK/AB010165
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GENBANK/AB010166
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GENBANK/AB010167
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GENBANK/AB010168
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GENBANK/AB010169
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GENBANK/AB010170
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GENBANK/AB010171
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GENBANK/AB010172
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GENBANK/AB010173
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GENBANK/AB010174
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GENBANK/AB010175
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GENBANK/AB010176
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GENBANK/AB010177
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GENBANK/AB010178
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GENBANK/AB010179
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GENBANK/AB010180
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GENBANK/AB010181
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GENBANK/AB010182
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GENBANK/AB010183
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GENBANK/AB010184